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P53 is the most frequently mutated gene in human cancer 37. When the p53 gene become mutated it gives rise to a stable mutant protein whose accumulation is regarded as a hallmark of cancer cells. Gastric Cancer Carcinoma Management 21 638 Jpg 638 479 Pixels Gastric Cancer Gastric Carcinoma Lymphatic The click learn presents different types of genes that when mutated contribute to cancer including oncogenes tumor suppressor genes and dna repair genes. P53 gene cancer . This tumor suppressor and transcription factor regulates several genes that protect against neoplastic transformation including those involved in the modulation of the cell cycle dna repair apoptosis senescence angiogenesis and metabolism 38. The p53 gene tp53 is a gene that is mutated in many cancers and is the most common gene mutation found in cancer cells. Emerging evidence from laboratories and clinical trials shows that some small molecule inhibitors exert anti cancer effect via reactivation and restoration of p...